Aveo kidney cancer drug more tolerated than Nexavar
(Reuters) Patients taking canada goose black friday sale a kidney cancer drug being developed by Aveo Pharmaceuticals Inc were half as Canada Goose online likely canada goose clearance sale to Canada Goose Coats On Sale need a break from the medication due to side effects than those on the widely used medicine Nexavar, according to data released on Wednesday.
There were also significantly fewer patients taking Aveo tivozanib who required a dose reduction than those on Nexavar.
Aveo, which is developing tivozanib along with Japan Astellas Pharma, had already released preliminary data from canada goose clearance the pivotal study showing that its drug delayed worsening of canada goose uk outlet the disease longer than Nexavar, sold by Bayer AG and Onyx Pharmaceuticals.
The latest data, to be presented at next month American Society of canada goose uk shop Clinical Oncology (ASCO) meeting in Chicago, focused on safety and tolerability of https://www.canadagooseoutleta.com Canada Goose Online the Aveo drug. It is being positioned as a potential front line, or initial treatment, uk canada goose outlet for kidney canada goose coats on sale cancer.
attractive feature for tivozanib is canadian goose jacket both the efficacy cheap canada goose uk and the safety profile, Dr Robert Motzer, the study lead investigator and an Canada Goose Jackets attending physician at Memorial Sloan Kettering Cancer Center, said in a telephone interview. and European approval for canada goose tivozanib to treat renal cell Canada Goose sale carcinoma later this year. JP Morgan analysts have predicted 2013 approval and forecast annual sales reaching $590 million by 2015.
Due buy canada goose jacket to toxicities associated with kidney cancer treatments, patients canada goose coats often canada goose store require an interruption in the medication or Canada Goose Outlet a reduction in the dose.
In the 517 canada goose uk black friday patient Phase III study, 18 percent of tivozanib patients needed dosing interruptions due to side effects, compared with 35 percent for Nexavar, also known as sorafenib.
The rate of patients requiring dose reductions was 14 percent for tivozanib compared with 44 percent for Nexavar. The results were deemed to be statistically significant, Aveo said.
Patients taking tivozanib had slightly higher incidence of high blood pressure and fatigue, while those who received Nexavar in the study reported a higher incidence of diarrhea and hand foot syndrome, an uncomfortable skin condition that resembles a sunburn.
Motzer noted that one of the most important features of Nexavar has been cheap Canada Goose its safety compared with other buy canada goose jacket cheap widely used kidney cancer drugs, making the results canada goose factory sale for Aveo treatment all the more significant.
seems to canada goose outleta have very few effects like skin toxicity or diarrhea or fatigue that we see Canada Goose Parka frequently in day to day management of uk canada goose kidney cancer, Motzer said.
In previously released data, tivozanib delayed worsening of the cancer, known as progression free survival, or PFS, by an average of 11.9 months versus 9.1 months for Nexavar. PFS was the study primary goal.